Mag ich Unglück nit widerstan, which bears the acrostic “Maria” in all its differing text versions, is a Lied that came to be known as the “Song of the Queen of Hungary.” Although Mary of Hungary, the sister and confidant of Charles V, never openly confessed to her liking for the Reformation, Mag ich Unglück with a sacred text variant is included in many of the protestant hymnbooks. But the earliest known witness of the Lied is a setting by Ludwig Senfl that for the first time appears in 1523. The popularity of the song itself seems to have been influenced by its connection with major topics of the time which also apply to Mary’s life and fate: love, death and questions of faith. The article attempts to gather information for a possible genesis of the text variants of the song, and sets them in relation to other acrostic-songs for members of aristocratic circles. It furthermore pursues the contexts in which the song and various contrafacta were placed in pamphlets throughout the 16th century thus reflecting events in the early years of the Reformation in the German-speaking realm.