Molecular mechanisms of resistance/sensitivity of breast cancer against the ErbB-Inhibitor Pelitinib (EKB-569)

Caroline Brünner-Kubath

doi:10.25365/thesis.5829

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Title (eng)

Molecular mechanisms of resistance/sensitivity of breast cancer against the ErbB-Inhibitor Pelitinib (EKB-569)

Parallel title (deu)

Molekulare Mechanismen der Resistenz/Sensibilität in Brustkrebs gegenüber dem ErbB-Inhibitor Pelitinib (EKB-569)

Author

Caroline Brünner-Kubath

Adviser

Thomas Decker

Assessor

Thomas Decker

Abstract (deu)

Die Diplomarbeit handelt von zwei Brustkrebszellinien SKBR3 und T47D, die entweder resistent oder sensibel gegenüber dem EGFR/ErbB-2 Tyrosinkinase Inhibitor Pelitinib sind. Pelitinib wirkt auf das Zellwachstum und den ErbB Signalweg.

Abstract (eng)

The studies are about SKBR3 and T47D, two human breast cancer cells which proved to be sensitive and resistant against the particular Epidermal Growth Factor Receptor (EGFR)/ErbB-2 receptor tyrosine kinase inhibitor pelitinib (EKB-569, Wyeth). This novel irreversible ErbB inhibitor showed effects on the growth activity and on ErbB-triggered signaling.

Keywords (eng)

breast cancerSKBR3T47Dtyrosine kinase receptortyrosine kinase inhibitorpelitinibresistancesensibility

Keywords (deu)

BrustkrebsSKBR3T47DTyrosinkinase RezeptorTyrosinkinase InhibitorPelitinibResistenzSensibilität

Subject (deu)

Subject (deu)

Subject (deu)

Type (deu)