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Title (deu)
The nucleosome as the ``hydrogen atom" of epigenetics.
Speaker / Lecturer
Alexey Onufriev
Virginia Tech
Description (deu)

Just like the electronic energy levels in the hydrogen atom, structural transitions in the nucleosome are characterized by the appropriate (free) energy scales, which sets a useful framework for understanding the nucleosome function. Further, these energy scales and the corresponding transitions can be modulated by external ``fields", which, in the case of the nucleosome, includes intra-cellular pH. Surprisingly, biologically relevant small variations of intra-cellular pH can have significant effect on stability of the nucleosome, which may lead to multiple biological consequences.

Keywords (deu)
Chromatin ModelingMathematicsPhysicsComputationBiologyMedicine
Subject (eng)
ÖFOS 2012 -- 101 -- Mathematics
Type (eng)
Language
[eng]
Persistent identifier
https://phaidra.univie.ac.at/o:2063445
Date created
2024-03-05
Place of creation (eng)
ESI
Duration
28 minutes 23 seconds
Content
Details
Object type
Video
Format
video/mp4
Created
18.04.2024 04:37:50
Metadata