Titel
Ancient origins of arthropod moulting pathway components
Autor*in
Abstract
Ecdysis (moulting) is the defining character of Ecdysoza (arthropods, nematodes and related phyla). Despite superficial similarities, the signalling cascade underlying moulting differs between Panarthropoda and the remaining ecdysozoans. Here, we reconstruct the evolution of major components of the ecdysis pathway. Its key elements evolved much earlier than previously thought and are present in non-moulting lophotrochozoans and deuterostomes. Eclosion hormone (EH) and bursicon originated prior to the cnidarian-bilaterian split, whereas ecdysis-triggering hormone (ETH) and crustacean cardioactive peptide (CCAP) evolved in the bilaterian last common ancestor (LCA). Identification of EH, CCAP and bursicon in Onychophora and EH, ETH and CCAP in Tardigrada suggests that the pathway was present in the panarthropod LCA. Trunk, an ancient extracellular signalling molecule and a well-established paralog of the insect peptide prothoracicotropic hormone (PTTH), is present in the non-bilaterian ctenophore Mnemiopsis leidyi. This constitutes the first case of a ctenophore signalling peptide with homology to a neuropeptide.
Stichwort
General Biochemistry, Genetics and Molecular BiologyGeneral Immunology and MicrobiologyGeneral NeuroscienceGeneral Medicine
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
eLife
Band
8
ISSN
2050-084X
Erscheinungsdatum
2019
Publication
eLife Sciences Publications, Ltd
Projekt
Kod / Identifikator
P29455-B29
Fördergeber
Erscheinungsdatum
2019
Zugänglichkeit
Rechte
Rechteangabe
© 2019, de Oliveira et al.
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