Titel
Synthesis, Modification, and Biological Evaluation of a Library of Novel Water‐Soluble Thiopyridone‐Based Organometallic Complexes and Their Unexpected (Biological) Behavior
Autor*in
Marius Ozenil
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna
... show all
Abstract
A series of 16 dinuclear thiopyridone-based organometallics with excellent water solubility, increased stability and remarkable cytotoxicity were synthesized and characterized. The complexes of this work formed dimeric species featuring a double positive charge in polar protic solvents, accounting for their outstanding solubility in aqueous solution. Most of them displayed higher antiproliferative activity than their parental thiomaltol complex, with unexpected cytotoxicity trends depending on the employed metal center, ligand modification, and cell line. Insights into their behavior in biological systems were gathered by means of amino-acid interaction studies, cytotoxicity tests in 3D spheroid models, laser ablation, cellular accumulation measurements, as well as cell cycle experiments.
Stichwort
cancerhalf-sandwich complexesmetallodrugsorganometallicthiopyridones
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:1218405
Erschienen in
Titel
Chemistry – A European Journal
Band
26
Ausgabe
24
ISSN
0947-6539
Erscheinungsdatum
2020
Seitenanfang
5419
Seitenende
5433
Verlag
Wiley
Erscheinungsdatum
2020
Zugänglichkeit
Rechteangabe
(c) 2020 The Authors

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