Titel
Fiber consumption stimulates the activity of microbial bile salt hydrolases
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Abstract
Previously we reported a microbiota-dependent caloric restriction (CR)-triggered increase in the levels of taurine and taurine-conjugated bile acids (BA) in the gut. Now, we show that restrictive diets, including intermittent fasting and fasting-mimicking diet, had a similar impact to CR. The type of cage bedding that CR mice were housed with affected the levels of BAs and taurine in the ileum. Removal of cage bedding neutralized CR phenotype in terms of taurine levels, BAs deconjugation, and fecal microbiota composition. Microbiota transplant from CR mice housed with bedding increased BAs deconjugation. Inhibition of bile salt hydrolase (BSH) prevented the increase in free taurine concentration while increasing taurine-conjugated BA levels. Ad libitum consumption of diets high in fiber increased the levels of taurine conjugates but did not elevate the levels of BAs. Dietary restriction is required to stimulate BAs secretion, while ingestion of fiber stimulates the capacity of microbiota to deconjugate BAs.
Stichwort
Caloric restrictionIntestineMicrobiotaTaurineBile acids
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:2039840
Erschienen in
Titel
Journal of Functional Foods
Band
107
ISSN
1756-4646
Erscheinungsdatum
2023
Verlag
Elsevier BV
Erscheinungsdatum
2023
Zugänglichkeit
Rechteangabe
© 2023 The Author(s)

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