Titel
Not the usual suspect – an unexpected organometallic product during the synthesis of cytotoxic platinum(ii) complexes
Autor*in
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Abstract
The reaction of (1R,2R)-(cyclohexane-1,2-diamine)dichloridoplatinum(II) with maleic acid unexpectedly resulted in the formation of an organometallic platinum(II) complex featuring a C,O-coordinating ligand. Additionally, a small series of close derivatives with increasing lipophilicity was synthesized. All complexes were fully characterized by multinuclear one- and two-dimensional (1H, 13C, 15N, and 195Pt) NMR spectroscopy, high resolution mass spectrometry, and in one case by X-ray diffraction. The lipophilicity and the impact on the DNA secondary structure as well as the cytotoxic properties in three human cancer cell lines (A549, SW480, and CH1/PA-1) were investigated. Unexpectedly, no clear-cut trend in cytotoxicity was observed with increasing lipophilicity. Also unexpectedly, the complexes showed only a low potential to inhibit cancer cell growth and no sign of interaction with DNA, in sharp contrast to the parent drug oxaliplatin, which seems to be caused by the low reactivity of the investigated compounds.
Stichwort
Inorganic Chemistry
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:2044747
Erschienen in
Titel
Dalton Transactions
Band
52
Ausgabe
44
ISSN
1477-9226
Erscheinungsdatum
2023
Seitenanfang
16326
Seitenende
16335
Publication
Royal Society of Chemistry (RSC)
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
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