Titel
Nanoimprinted Hierarchical Micro-/Nanostructured Substrates for the Growth of Cardiomyocyte Fibers
Autor*in
Michael M. Mühlberger
PROFACTOR GmbH
Autor*in
Sonja Kopp
PROFACTOR GmbH
Autor*in
Alison A. Deyett
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
... show all
Abstract
Investigating the behavior of cardiomyocytes is an important part of drug development. We present a structure and a related nanoimprint-based fabrication method, where the cardiomyocytes form isolated fibers, which is beneficial for drug testing, more closely representing the structure of the cardiomyocytes in vivo. We found that channel structures with walls with a rough top surface stimulate cardiomyocytes to form such fibers, as desired. Nanoimprint lithography is used as a fast and cost-efficient method to fabricate our hierarchically structured cell growth substrates.
Stichwort
nanoimprint lithographycell growthcardiomyocytesfiber formation
Objekt-Typ
Sprache
Englisch [eng]
Erschienen in
Titel
Nanomanufacturing
Band
3
Ausgabe
4
ISSN
2673-687X
Erscheinungsdatum
2023
Seitenanfang
416
Seitenende
433
Publication
MDPI AG
Projekt
Kod / Identifikator
871438
Projekt
Kod / Identifikator
W1232
Erscheinungsdatum
2023
Zugänglichkeit
Rechteangabe
© 2023 by the authors

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