Titel
PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo‐rescence Microscopy
Oliver J. V. Belleza
Centre of Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna
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Abstract
The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR−I emissions at λmax as long as 720 nm. Computational studies allow the development of a platform for the prediction of λmax and λEm. Furthermore, we demonstrate the compatibility of these novel fluorophores with live cell imaging in HEK293 cells, suggesting PyrAtes as potent intracellular markers.
Stichwort
FluorescenceDyesStokes shiftImidazo[1,2-a]pyridiniumFluorophore
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Angewandte Chemie International Edition
Band
63
Ausgabe
19
ISSN
1433-7851
Erscheinungsdatum
2024
Publication
Wiley
Projekt
Kod / Identifikator
W1232
Projekt
Kod / Identifikator
P33955
Projekt
Kod / Identifikator
682002
Fördergeber
Erscheinungsdatum
2024
Zugänglichkeit
Rechte
Rechteangabe
© 2024 The Authors
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