Titel
Elucidating the clinical and immunological value of m6A regulator-mediated methylation modification patterns in adrenocortical carcinoma
Autor*in
WENHAO XU
Department of Urology, Urological Surgery Research Institute, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing
HAOMING LI
Department of Urology, Affiliated Hospital of Guilin Medical University
YASIR HAMEED
Department of Applied Biological Sciences, Tokyo University of Science
... show all
Abstract
N6-methyladenosine methylation (m6A) is a common type of epigenetic alteration that prominently affects the prognosis of tumor patients. However, it is unknown how the m6A regulator affects the tumor microenvironment (TME) cell infiltration in adrenocortical carcinoma (ACC) and how it affects the prognosis of ACC patients yet. The m6A alteration patterns of 112 ACC patients were evaluated, furthermore, the association with immune infiltration cell features was investigated. The unsupervised clustering method was applied to typify the m6A alteration patterns of ACC patients. The principal component analysis (PCA) technique was taken to create the m6A score to assess the alteration pattern in specific malignancies. We found two independent patterns of m6A alteration in ACC patients. The TME cell infiltration features were significantly in accordance with phenotypes of tumor immune-inflamed and immune desert in both patterns. The m6Ascore also served as an independent predictive factor in ACC patients. The somatic copy number variation (CNV) and patients prognosis can be predicted by m6A alteration patterns. Moreover, the ACC patients with high m6A scores had better overall survival (OS) and higher efficiency in immune checkpoint blockade therapy. Our work demonstrated the significance of m6A alteration to the ACC patients immunotherapy. The individual m6A alteration patterns analysis might contribute to ACC patients prognosis prediction and immunotherapy choice.
Stichwort
m6ATumor microenvironmentAdrenocortical carcinomaImmunotherapyPrognosis
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Oncology Research
Band
31
Ausgabe
5
ISSN
0965-0407
Erscheinungsdatum
2023
Seitenanfang
819
Seitenende
831
Publication
Computers, Materials and Continua (Tech Science Press)
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
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