We analyze multipartite entanglement in systems of spin-1/2 particles from a relativistic perspective. General conditions which have to be met for any classification of multipartite entanglement to be Lorentz invariant are derived, which contributes to a physical understanding of entanglement classification. We show that quantum information in a relativistic setting requires the partition of the Hilbert space into particles to be taken seriously. Furthermore, we study exemplary cases and show how the spin and momentum entanglement transforms relativistically in a multipartite setting.