Titel
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression
Autor*in
Kirsten Aigner
Autor*in
Luise Descovich
Autor*in
W. Sommergruber
Boehringer Ingelheim Austria
... show all
Abstract
Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour–host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.
Stichwort
Epithelial to mesenchymal transitionInvasionTranscriptionDesmosomesCell adhesion
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:244160
Erschienen in
Titel
FEBS Letters
Band
581
Ausgabe
8
Seitenanfang
1617
Seitenende
1624
Erscheinungsdatum
01.01.2007
Universität Wien | Universitätsring 1 | 1010 Wien | T +43-1-4277-0