Titel
Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster
Autor*in
Alberto Agrisani
Department of Biology, University of Naples "Federico II"
Autor*in
Hakim Tafer
Institut für Biotechnologie, Universität für Bodenkultur
... show all
Abstract
A computational screen for novel small nucleolar RNAs in Drosophila melanogaster uncovered 15 novel snoRNAs and snoRNA-like long non-coding RNAs. In contrast to earlier surverys, the novel sequences are mostly poorly conserved and originate from unusual genomic locations. The majority derive from precurors antisense to well-known protein-coding genes, and four of the candidates are produced from exon-coding regions. Only a minority of the new sequences appears to have canonical target sites in ribosomal or small nuclear RNAs. Taken together, these evolutionary young, poorly conserved, and genomically atypical sequences point at a class of snoRNA-like transcripts with predominantly regulatory functions in the fruit fly genome.
Stichwort
snoRNAlong non-coding RNAsno-lncRNAsDrosophila
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:448435
Erschienen in
Titel
Non-Coding RNA
Band
1
Ausgabe
2
Seitenanfang
139
Seitenende
150
Verlag
MDPI AG
Erscheinungsdatum
2015
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