Abstract (eng)
According to Statistik Austria the life expectancy of women and men in Austria
has increased by 0,3% and 0,4% respectively between 2010 and 2011. To be
fit and healthy also at a higher age is a general desire and background of many
research projects.
It is important to prevent and to diagnose a disease on time, which could be
done by defining and evaluating certain biomarker.
Important parameters for chromosomal damage are micronuclei, nucleoplasmatic
bridges and buds whose frequency can be linked to an increased risk
for cancer, neuro-degenerative disorders and cardiovascular diseases.
The study entitled „The effects of the optimization of nutrition and exercise on
the health and mobility of elder people“ at the research platform „Active Ageing“
of the University Vienna is focusing on these and other parameters.
This thesis is part of this study and detects the parameter MNi, MNi total, NPBs,
NBUDs, necrosis, apoptosis, BMI, SPPB of 35 elderlies and links them to age
and gender.
The subjects were randomized into three groups (training, training & nutrition,
cognition group) and at time T1 (study started) mentioned parameters have
been investigated with the CBMN assay.
The decrease of MNi`s from the age of 70 years was also deserved in this
study.
There was a negative correlation between MNi and MNi total frequency with
rising age as well as a significant decline of necrosis frequency with age.
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The gender-specific difference, which was also seen in many studies, is visible
here, but without being significant, with increased MNi (p=0,210), MNi total
(p=0,201), NPBs (p=0,230) and NBUDs (p=0,334) in women. Further, necrotic
cells in women were noticeable raised in comparison to men (p=0,105).
A significant negative correlation has appeared between BMI and SPPB. On
the other hand the necrotic cells increased with rising BMI.
We expect that these examinations could deliver more significant results with
increasing the number of participants.
This first part of the total study shows no differences at baseline chromosomal
damage between groups and was able to confirm literature data regarding
chromosomal damage and age/gender.