Abstract (eng)
Macrophage proliferation plays an essential role in the maintenance of tissue homeostasis, during an infection, and for the recovery after an injury, especially in tissues, where monocytic influx is inhibited, e.g. the brain. The cyclin-dependent kinase 1 (Cdk1) was the first kinase identified and is the ’master regulator’ of the cell cycle. However, the role of Cdk1 in macrophages is unknown. Therefore, we generated a mouse-model with a Cdk1 deletion specific in myeloid cells, to determine the effect of Cdk1 on macrophage proliferation. Bone marrow-derived macrophages of Cdk1f l/f l LysM cre/cre mice were reduced and showed an impaired G2/M transition. Additionally, alveolar macrophages were also reduced in vivo. Large peritoneal macrophages were also reduced, but small periftoneal macrophages increased. Therefore, Cdk1 is important for the entry into mitosis during macrophage proliferation. In future, Cdk1 might me a promising target for pathologies, were macrophages proliferation either enhances or diminishes disease progression.