Titel
Trimethoprim-Loaded Microspheres Prepared from Low-Molecular-Weight PLGA as a Potential Drug Delivery System for the Treatment of Urinary Tract Infections
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Abstract
Commonly, therapy of urinary tract infections suffers from increasing resistance to antibiotics and the ability of uropathogenic Escherichia coli (UPEC) to invade bladder cells and cause recurring infections. As an alternative strategy for instillation into the bladder, trimethoprim-loaded microparticles with poly(d,l-lactic-co-glycolic acid) (PLGA) as a matrix were prepared. To reduce particle loss by washout, their surface was grafted with bioadhesive wheat germ agglutinin, providing biomimicry akin to UPEC. Since PLGA 503H has shown a slow drug release profile, the low-molecular-weight PLGA 2300 was studied. Whereas the drug loading of PLGA 503H particles amounted to 2.8%, the drug content of PLGA 2300 particles was twice as high. Although the drug release pattern started with an initial burst of 30% after 24 h for both PLGA types, half of the trimethoprim content was released after 4 days from PLGA 503H microparticles as opposed to 2 days in the case of PLGA 2300. Higher drug loading and accelerated release render PLGA 2300 a viable alternative to PLGA 503H.
Stichwort
Drug releaseAnatomyAntimicrobial agentsMicroparticlesCopolymers
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
ACS Omega
Band
5
Ausgabe
15
ISSN
2470-1343
Erscheinungsdatum
2020
Seitenanfang
9013
Seitenende
9022
Publication
American Chemical Society (ACS)
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
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