A-to-I RNA Editing Uncovers Hidden Signals of Adaptive Genome Evolution in Animals

Niko Popitsch; Christian D Huber; Ilana Buchumenski; Eli Eisenberg; Michael Jantsch; Arndt von Haeseler; Miguel Gallach

doi:10.1093/gbe/evaa046

Titel

A-to-I RNA Editing Uncovers Hidden Signals of Adaptive Genome Evolution in Animals

Autor*in

Niko Popitsch

Oxford NIHR Biomedical Research Center, Wellcome Trust Center for Human Genetics, University of Oxford

Christian D Huber

Australian Centre for Ancient DNA, The University of Adelaide

Ilana Buchumenski

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University

... show all

Abstract

In animals, the most common type of RNA editing is the deamination of adenosines (A) into inosines (I). Because inosines basepair with cytosines (C), they are interpreted as guanosines (G) by the cellular machinery and genomically encodedGalleles at edited sites mimic the function of edited RNAs. The contribution of this hardwiring effect on genome evolution remains obscure.We looked for population genomics signatures of adaptive evolution associated with A-to-I RNA edited sites in humans and Drosophila melanogaster. We found that single nucleotide polymorphisms at edited sites occur 3 (humans) to 15 times (Drosophila)more often than at unedited sites, the nucleotideGis virtually theunique alternative allele at edited sites andGalleles segregate at higher frequency at edited sites than at unedited sites.Our study reveals that a significant fraction of coding synonymous and nonsynonymous aswell as silent and intergenic A-to-I RNA editing sites are likely adaptive in the distantly related human and Drosophila lineages.

Stichwort

RNA editinghumanDrosophilanatural selection

Objekt-Typ

journal article

Sprache

Englisch [eng]

Persistent identifier

phaidra.univie.ac.at/o:1223977

DOI

10.1093/gbe/evaa046

Erschienen in

Titel