Titel
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
Autor*in
Jan Krivanek
Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
Ruslan A. Soldatov
Department of Biomedical Informatics, Harvard Medical School
Maria Eleni Kastriti
Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
... show all
Abstract
Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
Stichwort
Mesenchymal stem cellsOrganogenesisStem-cell niche
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Nature Communications
Band
11
ISSN
2041-1723
Erscheinungsdatum
2020
Publication
Springer Science and Business Media LLC
Projekt
Kod / Identifikator
647844
Fördergeber
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
© The Author(s) 2020
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