Titel
Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes
Autor*in
Toan Dao-Huy
Institute of Applied Synthetic Chemistry, TU Wien
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Abstract
A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-κB inhibition to establish a structure activity relationship. It was found that both, the side chain in position five and the substitution pattern of the aryl moiety in position two have a significant influence on the inhibitory activity.
Stichwort
NF-κB inhibitionnatural productlignanscross-couplingC-H activationdirect arylation
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Biomolecules
Band
10
Ausgabe
8
ISSN
2218-273X
Erscheinungsdatum
2020
Publication
MDPI AG
Projekt
Kod / Identifikator
S 10710
Fördergeber
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
© 2020 by the authors
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