Titel
Effects of Salinomycin and Deferiprone on Lead-Induced Changes in the Mouse Brain
Autor*in
Emilia Petrova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences
Autor*in
Yordanka Gluhcheva
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences
Autor*in
Ekaterina Pavlova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences
... show all
Abstract
Lead (Pb) is a highly toxic heavy metal that has deleterious effects on the central nervous system. This study aimed to investigate the effects of salinomycin (Sal) and deferiprone (DFP) on brain morphology and on the content of some essential elements in Pb-exposed mice. Adult male Institute of Cancer Research (ICR) mice were exposed to a daily dose of 80 mg/kg body weight ( b.w.) Pb(II) nitrate for 14 days and subsequently treated with Sal (16 mg/kg b.w.) or DFP (19 mg/kg b.w.) for another 14 days. At the end of the experimental protocol, the brains were processed for histological and inductively coupled plasma mass spectrometry (ICP-MS) analyses. Pb exposure resulted in a 50-fold increase in Pb concentration, compared with controls. Magnesium (Mg) and phosphorus (P) were also significantly increased by 22.22% and 17.92%, respectively. The histological analysis of Pb-exposed mice revealed brain pathological changes with features of neuronal necrosis. Brain Pb level remained significantly elevated in Sal- and DFP-administered groups (37-fold and 50-fold, respectively), compared with untreated controls. Treatment with Sal significantly reduced Mg and P concentrations by 22.56% and 18.38%, respectively, compared with the Pb-exposed group. Administration of Sal and DFP ameliorated brain injury in Pb-exposed mice and improved histological features. The results suggest the potential application of Sal and DFP for treatment of Pb-induced neurotoxicity.
Stichwort
Pb-induced neurotoxicitymouse brain histologyessential elementssalinomycindeferiprone
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:2046409
Erschienen in
Titel
International Journal of Molecular Sciences
Band
24
Ausgabe
3
ISSN
1422-0067
Erscheinungsdatum
2023
Verlag
MDPI AG
Projektnummer
BG 07/2019 – Bundesministerium für Bildung, Wissenschaft und Forschung (BMBWF)
Erscheinungsdatum
2023
Zugänglichkeit
Rechteangabe
© 2023 by the authors

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