Titel
Oxidative Stress Is a Concept, Not an Indication for Selective Antioxidant Treatment
Autor*in
Dov Lichtenberg
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University
Ilya Pinchuk
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University
Eleni Yonassi
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University
... show all
Abstract
The steady-state redox status is physiologically important and therefore homeostatically maintained. Changes in the status result in signaling (eustress) or oxidative damage (distress). Oxidative stress (OS) is a hard-to-quantitate term that can be estimated only based on different biomarkers. Clinical application of OS, particularly for selective antioxidant treatment of people under oxidative stress, requires quantitative evaluation and is limited by the lack of universal biomarkers to describe it. Furthermore, different antioxidants have different effects on the redox state. Hence, as long as we do not have the possibility to determine and quantify OS, therapeutic interventions by the “identify-and-treat” approach cannot be assessed and are, therefore, not likely to be the basis for selective preventive measures against oxidative damage.
Stichwort
quantitation of oxidative stressbiomarkersantioxidantsselective treatment
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:2065075
Erschienen in
Titel
Antioxidants
Band
12
Ausgabe
6
ISSN
2076-3921
Erscheinungsdatum
2023
Publication
MDPI AG
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
Rechteangabe
© 2023 by the authors
Universität Wien | Universitätsring 1 | 1010 Wien | T
+43-1-4277-0