Titel
A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies
Autor*in
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Abstract
A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.
Stichwort
Luotonin ATopoisomerase ICytotoxicityDockingG2/M arrest
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:2094690
Erschienen in
Titel
Bioorganic & Medicinal Chemistry
Band
28
Ausgabe
9
ISSN
0968-0896
Erscheinungsdatum
2020
Publication
Elsevier BV
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
© 2020 The Authors
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