Titel
Investigation of keratolytic impact of synthetic bolalipids on skin penetration of a model hydrophilic permeant
Autor*in
Simon Drescher
Phospholipid Research Center
... show all
Abstract
Synthetic single-chain bolalipids (SSCBs) are novel excipients in drug delivery, with potential as stabilizers or solubilizers. However, their impact on skin barrier function has not been comprehensively studied. Therefore, two SSCBs (PC-C24-PC and PC-C32-PC) were studied in aqueous systems for their impact on penetration of a model permeant into porcine skin. Concentrations of 0.05 – 5 % w/w were tested; PC-C24-PC formulations were low-viscosity liquids while PC-C32-PC formed viscous dispersions to gels at room temperature. Formulations were compared for their ability to enhance sodium fluorescein penetration (SF, 0.1 % w/w) into skin via tape stripping. Using NIR-densitometry, the effect of SSCB formulations on corneocyte cohesion was evaluated. Data were compared with phospholipid mixture Lipoid S-75, sodium dodecyl sulfate (SDS), and polyethylene glycol 12-hydroxystearate (PEG-HS), and distilled water as negative control. Contrary to the hypothesis, both SSCBs failed to increase SF penetration into the stratum corneum, but rather showed a significant decrease in penetration depth compared to water. Both SSCBs exhibited a keratolytic effect at 5 % w/w, leading to substantial removal of proteins from the skin surface. Consequently, SSCBs may not enhance penetration of hydrophilic drugs into skin, but could be used as keratolytic agents.
Stichwort
BolalipidsKeratolyticSkin barrierSkin penetrationSodium fluoresceinSurfactantsTape stripping
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:2114564
Erschienen in
Titel
European Journal of Pharmaceutics and Biopharmaceutics
Band
203
ISSN
0939-6411
Erscheinungsdatum
2024
Publication
Elsevier BV
Erscheinungsdatum
2024
Zugänglichkeit
Rechte
Rechteangabe
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