Titel
MSMS: A coalescent simulation program including recombination, demographic structure and selection at a single locus
Autor*in
Gregory Ewing
Max F. Perutz Laboratories
Joachim Hermisson
Max F. Perutz Laboratories (MFPL)
Joachim Hermisson
Max F. Perutz Laboratories (MFPL)
... show all
Abstract
Motivation: We have implemented a coalescent simulation program for a structured population with selection at a single diploid locus. The program includes the functionality of the simulator ms to model population structure and demography, but adds a model for deme- and time-dependent selection using forward simulations. The program can be used, e.g. to study hard and soft selective sweeps in structured populations or the genetic footprint of local adaptation. The implementation is designed to be easily extendable and widely deployable. The interface and output format are compatible with ms. Performance is comparable even with selection included.
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Bioinformatics
Band
26
Ausgabe
16
Seitenanfang
2064
Seitenende
2065
Erscheinungsdatum
01.09.2010
Zugänglichkeit
Rechte
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