Titel
Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut
Autor*in
Sabrina Borusak
Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz
Claudia Eberl
Max-von-Pettenkofer Institute, Ludwig Maximilian University Munich
... show all
Abstract
Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of Salmonella enterica, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that T. muris can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members.
Stichwort
BacteriologyMetagenomicsMicrobial ecologyMicrobiome
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:2065811
Erschienen in
Titel
Nature Communications
Band
14
ISSN
2041-1723
Erscheinungsdatum
2023
Publication
Springer Science and Business Media LLC
Fördergeber
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
Rechteangabe
© The Author(s) 2023
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